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Developing
a pipeline 
of first-in-class NAMPT inhibitors

Developing the first well-tolerated NAMPT inhibitor unlocks the potential of NAMPT as a drug target, with treatment opportunities across more than 20 diseases in which NAMPT is dysregulated.

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Developing a pipeline of first-in-class NAMPT inhibitors

Developing the first well-tolerated NAMPT inhibitor unlocks the potential of NAMPT as a drug target, with treatment opportunities across more than 20 diseases where NAMPT is dysregulated.

Developing the first well-tolerated NAMPT inhibitor unlocks the potential of NAMPT as a drug target, with treatment opportunities across more than 20 diseases where NAMPT is dysregulated.

Image-Blue-Overlay_Pipeline_2400x1180_edit-2.jpg

Developing a pipeline
of first-in-class NAMPT inhibitors

Image-Blue-Overlay_Pipeline_2400x1180_edit.jpg

Developing a pipeline of first-in-class NAMPT inhibitors

Developing the first well-tolerated NAMPT inhibitor unlocks the potential of NAMPT as a drug target, with treatment opportunities across more than 20 diseases where NAMPT is dysregulated.

Remedy Plan pipeline

We are advancing a pipeline of novel, hyperbolic NAMPT inhibitors, starting in oncology.

RPT1G, our lead asset, is in a Phase 1 trial (NCT#07107126) in patients with relapsed/refractory AML and higher-risk MDS. Our goal is to scale this drug pipeline to reach more patients suffering with solid tumor cancers, autoimmune disorders, and more.

Interested in exploring a collaboration?
Contact us at [email protected]

Interested in exploring a collaboration? Contact us at

Academic Collaborations 

Remedy Plan collaborates with leading academic institutions to explore the potential of our pipeline of unique NAMPT inhibitors.

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Collab 1

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Select Publications

Our research and progress has been featured at some of the most respected industry events, including the American Society of Hematology Annual Meeting, the American Association for Cancer Research Annual Meeting, and the American Society of Clinical Oncology Annual Meeting.

Phase 1, Open-Label, Multi-Center Trial of RPT1G in Patients with Relapsed/Refractory Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes/Neoplasms

American Society of Hematology Annual Meeting 2025

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First-in-Human Randomized Placebo-Controlled Phase 1 Study of RPT1G, a Novel Hyperbolic NAMPT Inhibitor for use in Acute Leukemias: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers

American Society of Hematology Annual Meeting 2025

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RPT1G, a Novel Hyperbolic NAMPT Inhibitor, is Highly Effective Against B-Cell Non-Hodgkin's Lymphoma with Germinal Center Origin

American Society of Hematology Annual Meeting 2025

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A Novel Hyperbolic NAMPT Inhibitor Reduces Fat Mass, but Not Lean Mass, in a Mouse Model of Obesity

Obesity Week 2025

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RPT1G, a first-in-class hyperbolic NAMPT inhibitor that avoids on-target toxicity

American Association for Cancer Research Annual Meeting 2025

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The Hyperbolic NAMPT Inhibitor RPT1G Synergizes with BCL-2 Family Inhibitors and Helps Overcome Venetoclax Resistance in Acute Myeloid Leukemia Cells

American Society of Hematology Annual Meeting 2024

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Synergistic effects of RPT1G, a first-in-class small molecule NAMPT inhibitor, with venetoclax and olaparib in hematological malignancies.

American Society of Clinical Oncology Annual Meeting 2024

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RPT1G: A 1st-in-Class Small Molecule NAMPT Inhibitor As a Novel Therapeutic for Acute Lymphocytic Leukemia

American Society of Hematology Annual Meeting 2023

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